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Journal of the Korean Child Neurology Society 2007;15(2):205-210.
Published online November 30, 2007.
Two Cases of Miller Fisher Syndrome without Ataxia.
Mi Ju, Kye Hyang Lee, Sook Young Kim
1Department of Pediatrics, Catholic University of Daegu, School of Medicine, Daegu, Korea. rosalia@cu.ac.kr
2Department of Ophthalmology, Catholic University of Daegu, School of Medicine, Daegu, Korea.
Abstract
A classic triad of acute external ophthalmoplegia, areflexia and ataxia characterizes Miller Fisher syndrome(MFS). Diagnosis is based on clinical findings and supported by two laboratory findings; CSF albuminocytological dissociation and serum anti-GQ1b IgG antibody testing. Anti-GQ1b antibody is a key factor in the pathogenesis of Miller Fisher syndrome and a useful marker in laboratory diagnosis. Here we report 2 cases with Miller Fisher syndrome without ataxia, whose major symptom was acute external ophthalmoplegia. Case 1 was associated with preceding Epstein-Barr virus infection and negative anti- GQ1b antibody. Case 2 was positive for the anti-GQ1b antibody. Both received intravenous immunoglobulin and fully recovered within 2 months after the onset of disease.
Key Words: Miller Fisher syndrome, Anti-GQ1b antibody


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