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Journal of the Korean Child Neurology Society 2011;19(2):115-123.
Published online August 30, 2011.
Clinical Manifestations of Leukodystrophies: A Single Center Study.
So Yeon Kang, Mi Sun Yum, Hae Won Choi, Eun Hye Lee, Tae Sung Ko, Han Wook Yoo
1Department of Pediatrics, Assan Medical Center, Chileren's Hospital University of Ulsan College of Medicine, Korea. tsko@amc.seoul.kr
2Department of Pediatrics, College of Medicine, Kyung Hee University, Korea.
Leukodystrophies have been defined as inherited metabolic disorders of myelin resulting in abnormal development or progressive destruction of the white matter. This study was performed to investigate the clinical manifestations and treatments of leukodystrophies in a single Korean tertiary center. METHODS: We retrospectively analysed the medical records of patients who had been diagnosed with leukodystrophy from May 1995 to May 2010 at the Asan Medical Center. RESULTS: During the 15-year study period, 36 cases of leukodystrophies were diagnosed with an verage age at symptom presentation of 49 months. Prominent symptoms at presentation were developmental delay (41%) and seizure (25%); however, nystagmus, developmental regression, hearing loss, gait disturbance, visual disturbance, attention deficit, hypotonia, hyperpigmentation, and hemiparesis were also observed. On MRI, periventricular involvement was noted frequently. The most common diagnoses were adrenoleukodystophy (25%), metachromatic leukodystrophy (11%), Krabbe disease (11%), and Pelizaeus-Merzbacher disease (8.3%). No final diagnosis was made in 14 cases (41%). Bone marrow transplantation was performed in 4 patients and showed favorable prognoses. CONCLUSION: Clinical features of leukodystrophies are not specific to diagnosis and most leukodystrophies remain undiagnosed; however, a logical algorithm based on prevalence could aid the laboratory testing. Because early detection and diagnosis is crucial for treatment and prognosis, it is important to have a high index of suspicion and watchful screening of familial history.
Key Words: Leukodystrophy, Adrenoleukodystrophy, Metachromatic leukodystrophy, Krabbe disease, Canavan disease, Pelizaeus-Merzbacher disease


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