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Journal of the Korean Child Neurology Society 2011;19(3):262-265.
Published online December 30, 2011.
Successful Desensitization of Oxcarbazepine: First Case in Pediatric Patient.
Ok Jeong Lee, Hee joon Yu, Cha Gon Lee, Sook Hyun Nam, Bo Lyun Lee, Jeehun Lee, Munhyang Lee
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan Univesity, School of Medicine, Seoul, Korea. hooni0101@hanmail.net
2Department of Pediatrics, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.
3Department of Pediatrics, Gangnam CHA hospital, College of Medicine, CHA University, Seoul, Korea.
Aromatic antiepileptic drugs (AEDs), such as diphenylhydantoin, phenobarbital, or carbamazepine (CBZ), are frequently associated with hypersensitivity reactions. This may restrict treatment options considerably due to cross reactivity with other aromatic AEDs. Desensitization can be very helpful for patients who show cross sensitivity with other AEDs. We report a case an 8-year-old patient who had cross sensitivity to oxcarbazepine (OXC) and CBZ and successfully managed by desensitization to OXC. The patient presented with intractable frontal lobe epilepsy. He had become seizure free with OXC; however OXC had to be discontinued due to whole body rash. CBZ also caused a hypersensitivity reaction. Therefore, OXC desensitization was attempted; he then had very subtle seizures during sleep with a frequency of 5 to 6 episodes per month on the 18th month of desensitization. Desensitization can be considered in a patient with limited treatment options due to hypersensitivity to aromatic AEDs.
Key Words: Oxcarbazepine, Carbamazepine, Cross reactivity, Desensitization
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