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Ann Child Neurol > Volume 26(4); 2018 > Article
Journal of the Korean Child Neurology Society 2018;26(4):284-287.
DOI: https://doi.org/10.26815/jkcns.2018.26.4.284    Published online December 31, 2018.
Tuberous Sclerosis Complex with Crohn’s Disease
Min Hee Kim1, Yoon Jin Lee2, Jae Young Kim3, Yoon Young Yi2, Joon Won Kang2,4
1Department of Medicine, College of Medicine, Chungnam National University, Daejeon, Korea
2Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea
3Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, Korea
4Department of Pediatrics & Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea
Correspondence:  Joon Won Kang, Tel: +82-42-280-8244, Fax: +82-42-255-3158, 
Email: childlove@cnu.ac.kr
Received: 8 October 2018   • Revised: 18 October 2018   • Accepted: 21 October 2018
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn`s disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.
Key Words: Tuberous sclerosis complex, Crohn’s disease, Subendothelial giant cell astrocytoma, Everolimus


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